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pentobarbital will lower the extent or effect of pimavanserin by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Keep an eye on. Avoid coadministration if possible. Check for lowered pimavanserin efficacy. An increase in pimavanserin dosage can be wanted.pentobarbital will lower the extent or effect of dienogest/estradiol valerat